药品试验结论翻译-世联翻译

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    【试验结论】
    翻译：【Test Conclusion】
    XXX4mg/kg剂量组雄性动物外周血白细胞总数、淋巴细胞和中性粒细胞绝对值、红细胞数、血细胞比积及磷酸肌酸激酶含量低于对照组；雌性动物各项观测指标与对照组比较没有明显变化。因此可以认为该剂量可引起雄性动物出现部分毒性反应，对于雌性大鼠而言为基本安全剂量。
    翻译：The total WBC count, absolute values of lymphocytes and neutrophilic leukocytes, RBC count, haematocrit and phosphocreatine kinase in the peripheral blood of male animals in the XXX4mg/kg group were lower than those in the control group; no significant changes were found in each observation indicator of female animals compared with the control group. Therefore, it is thought that this dosage can cause some toxic reactions on male animals, but it's basically safe for female rats.
    XXX12mg/kg剂量组雌性动物药后7天~28天、雄性动物药后28天至停药1个月体重增长低于对照组，雌性动物药后21天至28天进食量低于对照组，雌性及雄性动物分别有1~3只尿液潜血出现“中量”、“大量”的阳性变化，胆红素出现“+”的阳性变化，蛋白质出现“+~++”的阳性变化，外周血白细胞总数及淋巴细胞和中性粒细胞绝对值、外周血红细胞数、血细胞比积、血小板数、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶、甘油三酯、磷酸肌酸激酶、总蛋白、白蛋白、肌酐、胸腺重量及系数显着低于对照组。提示该剂量可引起动物出现毒性反应。停药1个月后除丙氨酸氨基转移酶、天门冬氨酸氨基转移酶仍有升高外，其它指标变化恢复。
    翻译：The weight growth of female animals 7～28 days after administration in the XXX12mg/kg group and male animals from the 28th day of administration to 1 month after withdraw was lower than that in the control group, and the food-intake quantity of female animals 21～28 days after administration was lower than that in the control group. 1～3 female and male animals respectively underwent “moderate” or “great” positive changes in urine occult blood (OB) test, “+” positive changes in bilirubin and “+～++” positive changes in protein. The total peripheral blood WBC count, absolute values of lymphocytes and neutrophilic leukocytes, peripheral blood RBC count, haematocrit, platelet count, alanine aminotransferase, aspartate amino transferase, alkaline phosphatase, TG, phosphocreatine kinase, total protein, albumin, creatinine, thymic weight and their coefficients were lower than those in the control group. This indicated that this dosage could cause toxic reactions on animals. One month after withdraw, changes of other indicators recovered except that the alanine aminotransferase and aspartate amino transferase were still increased.
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